Cholesterol content in the membrane promotes key lipid-protein interactions in a pentameric serotonin-gated ion channel

Volume: 15, Issue: 6, Pages: 061018 - 061018
Published: Nov 1, 2020
Abstract
Pentameric ligand-gated ion channels (pLGICs), embedded in the lipid membranes of nerve cells, mediate fast synaptic transmission and are major pharmaceutical targets. Because of their complexity and the limited knowledge of their structure, their working mechanisms have still to be fully unraveled at the molecular level. Over the past few years, evidence that the lipid membrane may modulate the function of membrane proteins, including pLGICs,...
Paper Details
Title
Cholesterol content in the membrane promotes key lipid-protein interactions in a pentameric serotonin-gated ion channel
Published Date
Nov 1, 2020
Volume
15
Issue
6
Pages
061018 - 061018
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