A cortical immune network map identifies distinct microglial transcriptional programs associated with β-amyloid and Tau pathologies
Abstract
Microglial dysfunction has been proposed as one of the many cellular mechanisms that can contribute to the development of Alzheimer’s disease (AD). Here, using a transcriptional network map of the human frontal cortex, we identify five modules of co-expressed genes related to microglia and assess their role in the neuropathologic features of AD in 540 subjects from two cohort studies of brain aging. Two of these transcriptional programs—modules...
Paper Details
Title
A cortical immune network map identifies distinct microglial transcriptional programs associated with β-amyloid and Tau pathologies
Published Date
Jan 14, 2021
Journal
Volume
11
Issue
1
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