Additional SNPs improve risk stratification of a polygenic hazard score for prostate cancer
Volume: 24, Issue: 2, Pages: 532 - 541
Published: Jan 8, 2021
Abstract
Polygenic hazard scores (PHS) can identify individuals with increased risk of prostate cancer. We estimated the benefit of additional SNPs on performance of a previously validated PHS (PHS46).180 SNPs, shown to be previously associated with prostate cancer, were used to develop a PHS model in men with European ancestry. A machine-learning approach, LASSO-regularized Cox regression, was used to select SNPs and to estimate their coefficients in...
Paper Details
Title
Additional SNPs improve risk stratification of a polygenic hazard score for prostate cancer
Published Date
Jan 8, 2021
Volume
24
Issue
2
Pages
532 - 541
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