PTEN deficiency leads to proteasome addiction: a novel vulnerability in glioblastoma

Glioblastoma (GBM) is the most common primary brain tumor in adults with a median survival of approximately 15 months; therefore, more effective treatment options for GBM are required. To identify new drugs targeting GBMs, we performed a high-throughput drug screen using patient-derived neurospheres cultured to preferentially retain their glioblastoma stem cell (GSC) phenotype.High-throughput drug screening was performed on GSCs followed by a...