Physical interaction between BAALC and DBN1 induces chemoresistance in leukemia

•Overexpression of BAALC is a poor prognostic factor in various types of leukemia.•We identified the actin-related protein Drebrin1 as a binding partner of BAALC.•The BAALC–Drebrin1 complex was found to contribute to the chemoresistance of cytarabine.•Disrupting this complex canceled its chemoresistance capacity. BAALC is identified as a leukemia-associated gene and is highly expressed in CD34-positive hematopoietic stem cells. High BAALC...