Tract‐specific analysis and neurocognitive functioning in sickle cell patients without history of overt stroke

Introduction Sickle cell disease (SCD) is a hereditary blood disorder in which the oxygen‐carrying hemoglobin molecule in red blood cells is abnormal. SCD patients are at increased risks for strokes and neurocognitive deficit, even though neurovascular screening and treatments have lowered the rate of overt strokes. Tract‐specific analysis (TSA) is a statistical method to evaluate microstructural WM damage in neurodegenerative disorders, using...