Genetic insights into the biological mechanisms governing human ovarian ageing

Published: Jan 15, 2021
Abstract
null Reproductive longevity is critical for fertility and impacts healthy ageing in women, yet insights into the underlying biological mechanisms and treatments to preserve it are limited. Here, we identify 290 genetic determinants of ovarian ageing, assessed using normal variation in age at natural menopause (ANM) in ∼200,000 women of European ancestry. These common alleles influence clinical extremes of ANM; women in the top 1% of genetic...
Paper Details
Title
Genetic insights into the biological mechanisms governing human ovarian ageing
Published Date
Jan 15, 2021
Journal
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