Development of a High-Throughput Assay to Identify Inhibitors of ENPP1
Abstract
The innate immune response to cancer is initiated by cytosolic DNA, where it binds to cGAS and triggers type I interferon (IFN) expression via the STING receptor, leading to activation of tumor-specific T cells. Ectonucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1) has been identified as the primary enzyme responsible for degrading cGAMP, and therefore it is under intense investigation as a therapeutic target for cancer immunotherapy. ENPP1...
Paper Details
Title
Development of a High-Throughput Assay to Identify Inhibitors of ENPP1
Published Date
Jun 1, 2021
Journal
Volume
26
Issue
5
Pages
740 - 746
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