RNA-assisted self-assembly of monomeric antigens into virus-like particles as a recombinant vaccine platform
Abstract
Representing highly ordered repetitive structures of antigen macromolecular assemblies, virus-like particles (VLPs) serve as a high-priority vaccine platform against emerging viral infections, as alternatives to traditional cell culture-based vaccines. RNAs can function as chaperones (Chaperna) and are extremely effective in promoting protein folding. Beyond their canonical function as translational adaptors, tRNAs may moonlight as chaperones...
Paper Details
Title
RNA-assisted self-assembly of monomeric antigens into virus-like particles as a recombinant vaccine platform
Published Date
Feb 1, 2021
Journal
Volume
269
Pages
120650 - 120650
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