Type I diabetes suppresses intracellular calcium ion increase normally evoked by heat stress in rat skeletal muscle

Heat stress, via its effects on muscle intracellular Ca 2+ concentrations ([Ca 2+ ] i ), has been invoked as a putative therapeutic countermeasure to type 1 diabetes-induced muscle atrophy. Using a circulation- and neurally intact in vivo muscle preparation, we tested the hypothesis that impaired muscle Ca 2+ homeostasis in type 1 diabetic rats is due to attenuated heat stress tolerance mediated via transient receptor potential vanilloid 1...