A Transcriptional State Driven by Yin Yang 1 Confers a Therapeutic Vulnerability in Glioblastoma Stem Cells
Abstract
Glioblastoma (GBM) is the most lethal primary brain cancer characterized by resistance to chemotherapy and radiotherapy, which is driven by GBM stem cells (GSCs). Here, we interrogated gene expression profiles and whole genome CRISPR/Cas9 screening in a large panel of patient-derived GSCs, differentiated glioblastoma cells (DGCs), and neural stem cells (NSCs) to identify master regulators of GSC stemness, revealing a dependency on Yin Yang 1...
Paper Details
Title
A Transcriptional State Driven by Yin Yang 1 Confers a Therapeutic Vulnerability in Glioblastoma Stem Cells
Published Date
Jan 1, 2020
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