Germinal BRCA1-2 pathogenic variants (gBRCA1-2pv) and pancreatic cancer: epidemiology of an Italian patient cohort

U. Peretti; Alessandro Cavaliere; Monica Niger; G. Tortora; M. Di Marco; Maria Grazia Rodriquenz; F. Centonze; I.G. Rapposelli; G. Giordano; F. De Vita; Michele Reni

doi:https://doi.org/10.1016/j.esmoop.2020.100032

doi.org/10.1016/j.esmoop.2020.100032

Germinal BRCA1-2 pathogenic variants (gBRCA1-2pv) and pancreatic cancer: epidemiology of an Italian patient cohort

,

,

..., Michele Reni

59

ESMO Open7.30

Volume: 6, Issue: 1, Pages: 100032 - 100032

Published: Feb 1, 2021

Abstract

Germline BRCA1-2 pathogenic variants (gBRCApv) increase the risk of pancreatic cancer and predict for response to platinating agents and poly(ADP-ribose) polymerase inhibitors. Data on worldwide gBRCApv incidence among pancreatic ductal adenocarcinoma (PDAC) patients are sparse and describe a remarkable geographic heterogeneity. The aim of this study is to analyze the epidemiology of gBRCApv in Italian patients.Patients of any age with...

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Paper Details

Title

Germinal BRCA1-2 pathogenic variants (gBRCA1-2pv) and pancreatic cancer: epidemiology of an Italian patient cohort

DOI

doi.org/10.1016/j.esmoop.2020.100032

Published Date

Feb 1, 2021

Journal

ESMO Open

Volume

6

Issue

1

Pages

100032 - 100032

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