Enantioselective C( sp 3 )–C( sp 3 ) cross-coupling of non-activated alkyl electrophiles via nickel hydride catalysis
Abstract
Cross-coupling of two alkyl fragments is an efficient method to produce organic molecules rich in sp3-hybridized carbon centres, which are attractive candidate compounds in drug discovery. Enantioselective C(sp3)-C(sp3) coupling is challenging, especially of alkyl electrophiles without an activating group (aryl, vinyl, carbonyl). Here, we report a strategy based on nickel hydride addition to internal olefins followed by nickel-catalysed...
Paper Details
Title
Enantioselective C( sp 3 )–C( sp 3 ) cross-coupling of non-activated alkyl electrophiles via nickel hydride catalysis
Published Date
Mar 1, 2021
Journal
Volume
13
Issue
3
Pages
270 - 277
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