TAM kinase inhibition and immune checkpoint blockade– a winning combination in cancer treatment?
Volume: 25, Issue: 2, Pages: 141 - 151
Published: Dec 31, 2020
Abstract
Introduction: Immune checkpoint inhibitors (ICI) have shown great promise in a wide spectrum of malignancies. However, responses are not always durable, and this mode of treatment is only effective in a subset of patients. As such, there exists an unmet need for novel approaches to bolster ICI efficacy.Areas covered: We review the role of the Tyro3, Axl, and Mer (TAM) receptor tyrosine kinases in promoting tumor-induced immune suppression and...
Paper Details
Title
TAM kinase inhibition and immune checkpoint blockade– a winning combination in cancer treatment?
Published Date
Dec 31, 2020
Volume
25
Issue
2
Pages
141 - 151
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