7β-(3-Ethyl-cis-crotonoyloxy)-1α-(2-methylbutyryloxy)-3,14-dehydro-Z Notonipetranone Attenuates Neuropathic Pain by Suppressing Oxidative Stress, Inflammatory and Pro-Apoptotic Protein Expressions.

Published on Jan 1, 2021in Molecules4.412
· DOI :10.3390/MOLECULES26010181
Amna Khan3
Estimated H-index: 3
(QAU: Quaid-i-Azam University),
Adnan Khan12
Estimated H-index: 12
(QAU: Quaid-i-Azam University)
+ 6 AuthorsSalman Khan19
Estimated H-index: 19
(QAU: Quaid-i-Azam University)
Source
Abstract
7β-(3-Ethyl-cis-crotonoyloxy)-1α-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone (ECN), a sesquiterpenoid obtained from a natural source has proved to be effective in minimizing various side effects associated with opioids and nonsteroidal anti-inflammatory drugs. The current study focused on investigating the effects of ECN on neuropathic pain induced by partial sciatic nerve ligation (PSNL) by mainly focusing on oxidative stress, inflammatory and apoptotic proteins expression in mice. ECN (1 and 10 mg/kg, i.p.), was administered once daily for 11 days, starting from the third day after surgery. ECN post-treatment was found to reduce hyperalgesia and allodynia in a dose-dependent manner. ECN remarkably reversed the histopathological abnormalities associated with oxidative stress, apoptosis and inflammation. Furthermore, ECN prevented the suppression of antioxidants (glutathione, glutathione-S-transferase, catalase, superoxide dismutase, NF-E2-related factor-2 (Nrf2), hemeoxygenase-1 and NAD(P)H: quinone oxidoreductase) by PSNL. Moreover, pro-inflammatory cytokines (tumor necrotic factor-alpha, interleukin 1 beta, interleukin 6, cyclooxygenase-2 and inducible nitric oxide synthase) expression was reduced by ECN administration. Treatment with ECN was successful in reducing the caspase-3 level consistent with the observed modulation of pro-apoptotic proteins. Additionally, ECN showed a protective effect on the lipid content of myelin sheath as evident from FTIR spectroscopy which showed the shift of lipid component bands to higher values. Thus, the anti-neuropathic potential of ECN might be due to the inhibition of oxidative stress, inflammatory mediators and pro-apoptotic proteins.
Download
References105
Newest
#1Samar Rezq (Zagazig University)H-Index: 9
#2Amira E. Alsemeh (Zagazig University)H-Index: 4
Last. Mona F. Mahmoud (Zagazig University)H-Index: 23
view all 7 authors...
We have previously demonstrated that the Thymus algeriensis and Thymus fontanesii extracts have powerful anti-inflammatory, antipyretic, and analgesic effects against acute pain models. We profiled their chemical composition and found many phenolic acids, flavonoids, and phenolic diterpenes. In this work, we investigated their antioxidant properties on HaCaT cells exposed to UVA-induced oxidative stress and examined their effects against chronic neuropathic pain and the underlying mechanisms. Th...
Source
#1Hassan Ali (QAU: Quaid-i-Azam University)H-Index: 7
#2Ashraf Ullah Khan (QAU: Quaid-i-Azam University)H-Index: 10
Last. Salman Khan (QAU: Quaid-i-Azam University)H-Index: 33
view all 8 authors...
Acute lung injury (ALI) together with acute respiratory distress syndrome (ARDS) are associated with high rate of mortality and morbidity in patients. In the current study, the anti-inflammatory effects of continentalic acid (CNT) in LPS-induced acute lung injury model was explored. The acute lung injury model was established by administering LPS (5 mg/kg) intraperitonealy. Following LPS administration, the survival rate, temperature changes and lung Wet/Dry ratio were assessed. The antioxidants...
Source
#1Wenyan ShanH-Index: 1
#2Xiaoyun LiaoH-Index: 1
Last. Jitong LiuH-Index: 1
view all 4 authors...
Source
#1Nancy S. YounisH-Index: 6
Last. Maged E. MohamedH-Index: 11
view all 3 authors...
Background: Myocardial infarction (MI) is still a major contributor to mortality worldwide, and therefore, searching for new drugs is an urgent priority. Natural products are a renewable source for medicinally and pharmacologically active molecules. The objective of this study was to explore the potential of geraniol, a monoterpene alcohol, to protect against MI. Methods: Five groups of Wister rats were used: a control group; a group treated only with geraniol; a group treated only with isoprote...
Source
#1Xiu-Qing Song (UJN: University of Jinan)H-Index: 4
#2Jia Sun (UJN: University of Jinan)H-Index: 3
Last. Hua Zhang (UJN: University of Jinan)H-Index: 12
view all 6 authors...
Abstract Six new compounds including four prenylated indole alkaloids (1–4) and two lignans (5–6), along with eight known cometabolites (7–14), were isolated from the flower buds of Tussilago farfara. Structures of the new compounds were elucidated by comparison with structurally related known analogues and also by comprehensive spectroscopic analyses. Their absolute configurations were determined by a variety of means including Mosher's method, Marfey's analysis, electronic circular dichroism (...
Source
#1Alexander PanossianH-Index: 34
#2Ean-Jeong SeoH-Index: 19
Last. Thomas EfferthH-Index: 95
view all 4 authors...
Source
#1Ashraf Ullah Khan (QAU: Quaid-i-Azam University)H-Index: 10
#2Amir Khan (QAU: Quaid-i-Azam University)H-Index: 4
Last. Salman Khan (QAU: Quaid-i-Azam University)H-Index: 33
view all 7 authors...
Abstract The sepsis is considered as serious clinic-pathological condition related with high rate of morbidity and mortality in critical care settings. In the proposed study, the hydrazides derivatives N-Benzylidene-4-((2-hydroxynaphthalene-1-yl) diazenyl) hydrazides (1–2) (NCHDH and NTHDH) were investigated against the LPS-induced sepsis in rodents. The NCHDH and NTHDH markedly improved the physiological sign and symptoms associated with the sepsis such as mortality, temperature, and clinical s...
Source
#1Kwangho Song (Kyung Hee University)H-Index: 6
#2Chu Won Nho (KIST: Korea Institute of Science and Technology)H-Index: 26
Last. Yeong Shik Kim (SNU: Seoul National University)H-Index: 77
view all 4 authors...
Tussilago farfara is a traditional herbal medicine used to treat coughs, bronchitis, and asthma. Its bioactive compounds include sesquiterpenoids with anti-inflammatory, antiproliferative, neuropro...
Source
#1Ya-Qun Zhou (HUST: Huazhong University of Science and Technology)H-Index: 16
#2Dai-Qiang Liu (HUST: Huazhong University of Science and Technology)H-Index: 9
Last. Da-Wei Ye (HUST: Huazhong University of Science and Technology)H-Index: 20
view all 9 authors...
Abstract Paclitaxel-induced neuropathic pain (PINP) is a dose-limiting side effect and is refractory to widely used analgesic drugs. Previous studies have demonstrated a protective role of peroxisome proliferator-activated receptor gama (PPARγ) in neuropathic pain. However, whether PPARγ activation could alleviate PINP remains to be elucidated. Our previous study has validated the analgesic effect of oltipraz, an nuclear factor erythroid-2 related factor 2 (Nrf2) activator, in a rat model of PIN...
Source
#1O. Morgan Hall (Tulane University)H-Index: 2
#2Alaina Broussard (Ochsner Medical Center)H-Index: 1
Last. Alan D. Kaye (LSU: Louisiana State University)H-Index: 61
view all 8 authors...
Capsaicin is a natural substance used to treat neuropathic pain because of its ability to be used in a more direct form on patients and efficiently treat their pain without the amount of side effects seen in the use of oral medications. Currently, the treatments for neuropathic pain are, control of the underlying disease process, then focused on symptomatic relief with pharmacotherapy, topical analgesics, or other interventions. When all pharmacological agents fail to relieve the pain, intervent...
Source
Cited By2
Newest
#1Adnan Khan (QAU: Quaid-i-Azam University)H-Index: 12
#2Bushra Shal (QAU: Quaid-i-Azam University)H-Index: 10
Last. Salman Khan (QAU: Quaid-i-Azam University)H-Index: 19
view all 10 authors...
Abstract null null Multiple Sclerosis (MS) is a chronic inflammatory demyelinating disorder of the central nervous system (CNS) that remains incurable. Withametelin (WMT), a phytosterol, showed diverse biological activities isolated from the leaves of Datura innoxa. In the present study, we used an in vitro model of HT22 and BV-2 cell lines and an in vivo murine model of MS, experimental autoimmune encephalomyelitis (EAE), to explore the antioxidant and anti neuroinflammatory potential of WMT. T...
Source
#1Muhammad Naveed (QAU: Quaid-i-Azam University)H-Index: 9
#2Rahim Ullah (UoP: University of Peshawar)H-Index: 7
Last. Salman Khan (QAU: Quaid-i-Azam University)H-Index: 33
view all 8 authors...
Source
The present study aims to determine the neuroprotective effect of Bergenin against spatial memory deficit associated with neurodegeneration. Preliminarily, the protective effect of Bergenin was observed against H2O2-induced oxidative stress in HT-22 and PC-12 cells. Further studies were performed in 5xFAD Tg mouse model by administering Bergenin (1, 30 and 60 mg/kg; orally), whereas Bergenin (60 mg/kg) significantly attenuated the memory deficit observed in the Y-maze and Morris water maze (MWM)...
Source
Vincristine (VCR) is a widely used chemotherapy drug that induced peripheral painful neuropathy. Yet, it still lacks an ideal therapeutic strategy. The transient receptor potential (TRP) channels, purinergic receptor (P2Y), and mitogen-activated protein kinase (MAPK) signaling play a crucial role in the pathogenesis of neuropathic pain. Withametelin (WMT), a potential Phytosteroid isolated from datura innoxa, exhibits remarkable neuroprotective properties. The present investigation was designed ...
Source
This website uses cookies.
We use cookies to improve your online experience. By continuing to use our website we assume you agree to the placement of these cookies.
To learn more, you can find in our Privacy Policy.