A novel soluble complement receptor 1 fragment with enhanced therapeutic potential
Abstract
Human complement receptor 1 (HuCR1) is a pivotal regulator of complement activity, acting on all three complement pathways as a membrane-bound receptor of C3b/C4b, C3/C5 convertase decay accelerator, and cofactor for factor I-mediated cleavage of C3b and C4b. In this study, we sought to identify a minimal soluble fragment of HuCR1, which retains the complement regulatory activity of the wildtype protein. To this end, we generated recombinant,...
Paper Details
Title
A novel soluble complement receptor 1 fragment with enhanced therapeutic potential
Published Date
Jan 1, 2021
Volume
296
Pages
100200 - 100200
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