Laboratory bioassay, greenhouse experiment and 3D‐QSAR studies on berberine analogues: a search for new herbicides based on natural products

BACKGROUND Berberine is a herbicidal chemical that we isolated from Coptis chinensis . In continuation of our program aimed at discovering and developing natural botanical herbicides, we evaluated the herbicidal activities of 39 berberine analogues and developed a three‐dimensional quantitative structure–activity relationship (3D‐QSAR) model. RESULTS Among these 39 analogs, the most active compounds were determined to be worenine chloride and...