Site-specific conjugation of native antibody
Abstract
Traditionally, non-specific chemical conjugations, such as acylation of amines on lysine or alkylation of thiols on cysteines, are widely used; however, they have several shortcomings. First, the lack of site-specificity results in heterogeneous products and irreproducible processes. Second, potential modifications near the complementarity-determining region may reduce binding affinity and specificity. Conversely, site-specific methods produce...
Paper Details
Title
Site-specific conjugation of native antibody
Published Date
Dec 8, 2020
Journal
Volume
3
Issue
4
Pages
271 - 284
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History