Doxycycline ameliorates autophagy by inhibiting p38 MAPK in cardiac myocytes.

Published on Apr 1, 2021in International Journal of Cardiology3.229
· DOI :10.1016/J.IJCARD.2020.12.038
Lian-Jie Hou3
Estimated H-index: 3
(Guangzhou Medical University),
Mei-Ying Xie2
Estimated H-index: 2
+ 1 AuthorsGuo-Jun Zhao5
Estimated H-index: 5
(Guangzhou Medical University)
#1María Valero-Muñoz (BU: Boston University)H-Index: 12
#2Richard M. Wilson (BU: Boston University)H-Index: 11
Last. Flora Sam (BU: Boston University)H-Index: 37
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Abstract Background Immunoglobulin light chain (AL) cardiac amyloidosis is characterized by extracellular deposition of amyloid fibrils in the heart and is potentially fatal. Untreated, it manifests clinically as heart failure with a precipitous decline and a median survival of Methods/results Adult rat ventricular myocytes stimulated with AL (obtained from cardiac amyloidosis patients) increased MMP-2 and MMP-9 activities (P Conclusions These in vitro studies demonstrated that doxycycline, in a...
6 CitationsSource
#1Fang Gan (NAU: Nanjing Agricultural University)H-Index: 19
#2Yajiao Zhou (NAU: Nanjing Agricultural University)H-Index: 7
Last. Kehe Huang (NAU: Nanjing Agricultural University)H-Index: 26
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Abstract Ochratoxin A (OTA) is reported to induce nephrotoxicity in animals and humans. Porcine circovirus type 2 (PCV2) could induce porcine dermatitis and nephropathy syndrome. To date, little is known whether virus infection aggravates mycotoxin-induced toxicity. This work aimed to study the effects of PCV2 infection on OTA-induced nephrotoxicity and its mechanism in vivo and vitro. The results in vivo showed that PCV2 infection aggravated OTA-induced poor growth performance, nephrotoxicity, ...
11 CitationsSource
#1Jae Min ShinH-Index: 9
#2Ju Hyung KangH-Index: 8
Last. Heung Man Lee (KU: Korea University)H-Index: 27
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PURPOSE: Doxycycline has antibacterial and anti-inflammatory effects, and it also suppresses collagen biosynthesis. This study aimed to confirm the effects and mechanism of doxycycline on transforming growth factor (TGF) beta 1 induced epithelial-mesenchymal transition and cell migration in A549 and primary nasal epithelial cells. METHODS: A 3-(4,5-dimethylthiazol-2yl)-2,5-diphenyl-tetrazolium bromide assay and phalloidin-fluorescein isothiocyanate staining were used to evaluate cytotoxicity and...
4 CitationsSource
#1Yugang Liu (Southern Medical University)H-Index: 1
#2Jian ZhengH-Index: 1
Last. Yiwu Dai (Southern Medical University)H-Index: 1
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Fucoxanthin is rich in seaweed and considered as effective anti-cancer drug because of powerful antioxidant properties. The objective of this study was to investigate the role of fucoxanthin on apoptosis, invasion and migration of glioma cells. Firstly, fucoxanthin showed obvious cytotoxicity against human glioma cancer cell line U87 and U251, however, there was no inhibitory effect on normal neuron. And then, fucoxanthin induced apoptotic cell death showed by the condensation of chromatin mater...
41 CitationsSource
#1Flávia Viana Santa-Cecília (University of Paris)H-Index: 2
#2Benjamin Socias (University of Paris)H-Index: 1
Last. Rita Raisman-Vozari (University of Paris)H-Index: 36
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In neurodegenerative diseases, the inflammatory response is mediated by activated glial cells, mainly microglia, which are the resident immune cells of the central nervous system. Activated microglial cells release proinflammatory mediators and neurotoxic factors that are suspected to cause or exacerbate these diseases. We recently demonstrated that doxycycline protects substantia nigra dopaminergic neurons in an animal model of Parkinson’s disease. This effect was associated with a reduction of...
57 CitationsSource
#1Ki Tae Jung (Chosun University)H-Index: 9
#2Hak-Ryul Kim (Wonkwang University)H-Index: 15
Last. Seon-Hee Oh (Chosun University)H-Index: 18
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Cadmium (Cd) toxicity is associated with endoplasmic reticulum (ER) stress-mediated apoptosis and autophagy. However, the regulatory mechanisms responsible for the signaling pathways initiated by Cd are incompletely understood. Here, we investigated the involvement of glycogen synthase kinase (GSK) 3αβ and mitogen-activated protein kinases (MAPKs) in Cd toxicity. Cd-exposed H460 cells exhibited activation of JNK, p38, PERK, and CHOP and induction of autophagy and apoptosis; in contrast, levels o...
4 CitationsSource
Cited By1
#1Cong Duan (CAU: China Agricultural University)
#2Yi Liu (CAU: China Agricultural University)H-Index: 1
Last. Jiu-Feng Wang (CAU: China Agricultural University)H-Index: 14
view all 4 authors...
Abstract Porcine deltacoronavirus (PDCoV) is a swine enteropathogenic coronavirus (CoV) that continues to spread globally, placing strain on economic and public health. Currently, the pathogenic mechanism of PDCoV remains largely unclear, and effective strategies to prevent or treat PDCoV infection are still limited. In this study, the interaction between autophagy and PDCoV replication in LLC-PK1 cells was investigated. We demonstrated that PDCoV infection induced a complete autophagy process. ...