Synthesis and characterization of porous CaCO3 microspheres templated by yeast cells and the application as pH value-sensitive anticancer drug carrier

Using yeast as organic template and PDDA/PSS with opposite charge as polyelectrolyte, CaCO3 was deposited on yeast cells by Layer-by-Layer self-assembly method, and then porous calcium carbonate hybrid microspheres (CaCO3-HMPs) were prepared by calcination. The CaCO3-HMPs were characterized by FT-IR, XRD, SEM and TG. It was found that the prepared CaCO3-HMPs were nearly spherical, with visible pores on the surface, small particle size uniformity...