Expression and clinical importance of a newly discovered alternative splice variant of the gene for acrosin binding protein found in human brain tumors

Background Acrosin binding protein ( ACRBP ) is a member of the cancer–testis antigen (CTA) family. Normally, ACRBP mRNA is expressed only in seminiferous tubules, while abnormally it is expressed in various types of cancers in tumor tissues, such as brain tumor. Objectives To determine the expression and clinical impact of a newly discovered splice variant of ACRBP in brain tumor. Methods Total RNA was extracted and reverse transcribed from 92...