An update of prenylated phenolics: Food sources, chemistry and health benefits

Published on Feb 1, 2021in Trends in Food Science and Technology11.077
· DOI :10.1016/J.TIFS.2020.12.022
Sui Kiat Chang1
Estimated H-index: 1
(CAS: Chinese Academy of Sciences),
Yueming Jiang69
Estimated H-index: 69
(CAS: Chinese Academy of Sciences),
Bao Yang52
Estimated H-index: 52
(CAS: Chinese Academy of Sciences)
Sources
Abstract
Abstract Background Prenylated phenolics, a type of important bioactive compounds, present with prenyl group on the phenolic skeleton. Prenylated flavonoids, stilbenoids, courmarins and xanthones are representive subclasses of prenylated phenolics with impressive bioactivities. These bioactive chemicals are presented in food sources and afford them great health benefits. Scope and approach This review updates the prenylated phenolics identified from food sources. The sensory characteristics of dietary prenylated phenolics are highlighted. The bioavailabilities of dietary prenylated phenolics in relation to the health benefits in vivo are also discussed. Research findings on the health benefits of dietary prenylated phenolics from preclinical and clinical studies published within the last decade have been compiled and updated. Key findings and conclusions Novel dietary prenylated phenolics (stilbenoids, flavonoids, coumarins and xanthones) isolated from food sources are presented. They show better bioactivities than the phenolic precursors. Dietary prenylated phenolics are bioavailable in human with impressive health benefits, including antioxidation, anti-diabetic activity, obesity prevention, cardioprotection, immunomodulation, neuroprotection and osteoprotection. It is worthy to mention that some prenylated phenolics have desirable taste and flavour. Inclusion of dietary prenylated phenolics into human diet is highly desirable since they are good nutraceuticals.
📖 Papers frequently viewed together
18 Citations
204 Citations
3 Citations
References175
Newest
#1Jiali Yang (CAS: Chinese Academy of Sciences)H-Index: 11
#2Ting Zhou (CAS: Chinese Academy of Sciences)H-Index: 2
Last. Bao Yang (CAS: Chinese Academy of Sciences)H-Index: 52
view all 4 authors...
Abstract Prenylated flavonoids are good drug candidates due to multiple biological activities and health benefits. Prenyltransferase is an important enzyme involved in the biosynthesis of prenylated flavonoids. In this work, a flavonoid prenyltransferase (AhPT1) from Artocarpus heterophyllus showed an unexpectedly metal ion-induced specificity to flavonoid substrates. AhPT1 could catalyse 6-C-prenylation of genistein when Mg2+ serving as cofactor. Its catalytic activity to 6-hydroxyflavone was u...
1 CitationsSource
#1Lingrong Wen (CAS: Chinese Academy of Sciences)H-Index: 18
#2Dingding Shi (CAS: Chinese Academy of Sciences)H-Index: 4
Last. Bao Yang (CAS: Chinese Academy of Sciences)H-Index: 52
view all 7 authors...
Abstract Mulberry leaf is a vegetable used in daily diet. It can bring delicious taste and multiple health benefits. However, the chemicals responsible for these health benefits remain unveiled. In this work, two novel prenylated flavonoids were isolated from mulberry leaf. Their structures were identified and named as morachalcone D and morachalcone E. The protective effects of these two compounds were investigated, against endogenous oxidative damage (oxytosis/ferroptosis) induced by glutamate...
7 CitationsSource
#1Anna BoronatH-Index: 7
Last. Rafael de la TorreH-Index: 59
view all 6 authors...
Beer is a fermented beverage with beneficial phenolic compounds and is widely consumed worldwide. The current study aimed to describe the content of three families of phenolic compounds with relevant biological activities: prenylated flavonoids (from hops), simple phenolic alcohols (from fermentation) and alkylresorcinols (from cereals) in a large sample of beers (n = 45). The prenylated flavonoids analyzed were xanthohumol, isoxanthohumol, 6- and 8-prenylnaringenin. The total prenylated flavono...
8 CitationsSource
#1Jingran Fan (Beijing University of Chinese Medicine)H-Index: 2
#2Yi Kuang (PKU: Peking University)H-Index: 10
Last. Min Ye (PKU: Peking University)H-Index: 36
view all 8 authors...
Glycyrrhiza uralensis (liquorice) is a well-known medicinal plant. Its roots and rhizomes are used as the popular Chinese herbal medicine Gan-Cao. An ethanol extract of the aerial parts of G. urale...
1 CitationsSource
#1Ibrahim Kalle Kwaifa (UPM: Universiti Putra Malaysia)H-Index: 1
#2Hasnah Bahari (UPM: Universiti Putra Malaysia)H-Index: 6
Last. Sabariah Md Noor (UPM: Universiti Putra Malaysia)H-Index: 5
view all 4 authors...
Obesity is characterized by the excessive deposition of fat that may interfere with the normal metabolic process of the body. It is a chronic condition associated with various metabolic syndromes, whose prevalence is grossly increasing, and affects both children and adults. Accumulation of excessive macronutrients on the adipose tissues promotes the secretion and release of inflammatory mediators, including interleukin-6 (IL-6), interleukin 1β, tumor necrotic factor-α (TNF-α), leptin, and stimul...
13 CitationsSource
#1Yan-Hui Fu (Hainan Normal University)H-Index: 1
#2Jia-Ming Guo (Hainan Normal University)H-Index: 3
Last. Yan-Ping Liu (Hainan Normal University)H-Index: 4
view all 8 authors...
Artocarpus heterophyllus (jack tree) is an evergreen fruit tree belonging to the genus Artocarpus (Moraceae), which is widely distributed in subtropical and tropical regions of Asia. Its fruits (jackfruit), well-known as the world’s largest tree-borne fruit, are being consumed in our daily diets as a very popular tropical fruit throughout the world and have been confirmed to hold various health benefits. In this study, five new prenylated chromones, artocarheterones A–E (1–5), as well as seven k...
3 CitationsSource
#1Clementina M.M. Santos (IPN: Instituto Politécnico Nacional)H-Index: 14
#1Clementina M.M. Santos (IPN: Instituto Politécnico Nacional)H-Index: 2
Last. Artur M. S. Silva (University of Aveiro)H-Index: 45
view all 2 authors...
Prenylated flavonoids combine the flavonoid moiety and the lipophilic prenyl side-chain. A great number of derivatives belonging to the class of chalcones, flavones, flavanones, isoflavones and other complex structures possessing different prenylation patterns have been studied in the past two decades for their potential as antioxidant agents. In this review, current knowledge on the natural occurrence and structural characteristics of both natural and synthetic derivatives was compiled. An exha...
5 CitationsSource
#1Che Chuan Wang (STUST: Southern Taiwan University of Science and Technology)H-Index: 4
#2Yu Hsuan Ho (FJU: Fu Jen Catholic University)H-Index: 1
Last. Su-Jane Wang (FJU: Fu Jen Catholic University)H-Index: 22
view all 5 authors...
Abstract Excitotoxicity induced by excessive glutamate has been implicated in many brain disorders. Xanthohumol is a natural product derived from hops (Humulus lupulus L.), which is reported to have glutamate release-inhibiting activity. However, it is unknown whether xanthohumol has protective effects against glutamate-induced excitotoxicity. This study investigated the potential action of xanthohumol in a rat model of excitotoxicity induced by intraperitoneal injection of kainic acid (KA). Xan...
7 CitationsSource
#1Lingling Fang (Arkansas State University)H-Index: 4
#2Tianhong Yang (Arkansas State University)H-Index: 8
Last. Fabricio Medina-Bolivar (Arkansas State University)H-Index: 17
view all 3 authors...
Prenylated stilbenoids are phenolic compounds produced in a small number of plants such as peanut (Arachis hypogaea) to counteract biotic and abiotic stresses. In addition to their role in plant defense, they exhibit biological activities with potential application in human health. Whereas non-prenylated stilbenoids such as resveratrol are commercially available, the availability of prenylated stilbenoids is limited. To this end, hairy root cultures of peanut were developed as an elicitor-contro...
4 CitationsSource
#1Yan-Ping Liu (CPU: China Pharmaceutical University)H-Index: 4
#2Gui YanH-Index: 4
Last. Yan-Hui FuH-Index: 7
view all 8 authors...
Manilkara zapota, usually known as Sapodilla, is a fairly slow-growing evergreen tropical tree which belongs to the genus Manilkara (Sapotaceae), indigenous to Central America, southern Mexico, and the Caribbean. The ripe fruits of M. zapota have been widely consumed as an uniquely flavored tropical fruit and verified to hold a variety of health benefits. In order to investigate the potential health-promoting chemical compositions from the fruits of M. zapota cultivated in Hainan Island of China...
7 CitationsSource
Cited By1
Newest