Making, Cloning, and the Expression of Human Insulin Genes in Bacteria: The Path to Humulin
Abstract
In the mid- to late 1970s, recombinant deoxyribonucleic acid methods for cloning and expressing genes in E. coli were under intense development. The important question had become: Can humans design and chemically synthesize novel genes that function in bacteria? This question was answered in 1978 and in 1979 with the successful expression in E. coli of 2 mammalian hormones, first somatostatin and then human insulin. The successful production of...
Paper Details
Title
Making, Cloning, and the Expression of Human Insulin Genes in Bacteria: The Path to Humulin
Published Date
Dec 19, 2020
Journal
Volume
42
Issue
3
Pages
374 - 380
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