Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice
Abstract
In vertebrates, the type 1 parathyroid hormone receptor (PTH1R) is a critical regulator of skeletal development and homeostasis; however, how it is modulated is incompletely understood. Here we report that deleting Kindlin-2 in osteoblastic cells using the mouse 10-kb Dmp1-Cre largely neutralizes the intermittent PTH-stimulated increasing of bone volume fraction and bone mineral density by impairing both osteoblast and osteoclast formation in...
Paper Details
Title
Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice
Published Date
Dec 1, 2020
Volume
5
Issue
1
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