Modafinil‐coated nanoparticle increases expressions of brain‐derived neurotrophic factor, glial cell line‐derived neurotrophic factor and neuronal nuclear protein, and protects against middle cerebral artery occlusion‐induced neuron apoptosis in the rat hippocampus

The present study investigates the neuroprotective effects of modafinil-coated nanoparticle in rats' hippocampal CA1 region. Male Wistar rats (n = 48) were randomly divided into four groups. Then middle cerebral artery occlusion (MCAO) was performed by inserting a silicone coat filament in the right internal carotid artery via the external carotid artery until it reached the anterior cerebral artery. Modafinil (100 mg/kg) or modafinil-coated...