An interview with Roland (Roli) Peter Jakob, M.D.: biomaterials for orthoregeneration.

Published on Dec 23, 2020in Biomedical Materials3.174
· DOI :10.1088/1748-605X/ABA797
Myron Spector86
Estimated H-index: 86
(Brigham and Women's Hospital)
#2Paweł BąkowskiH-Index: 4
Last. Tomasz PiontekH-Index: 15
view all 5 authors...
Purpose. To determine the 5-year success rate of the "all-inside" technique of arthroscopic meniscus suture and collagen membrane wrapping along with bone marrow blood injection, to evaluate the progression of degenerative changes and the impact of simultaneous anteriro cruciate ligament (ACL) reconstruction. Methods. Fifty-four consecutive patients with complex meniscal tears were treated with the previously described technique. The subjective scores (International Knee Documentation Committee ...
3 CitationsSource
#1Myron Spector (VA Boston Healthcare System)H-Index: 86
1 CitationsSource
#1Myron Spector (Brigham and Women's Hospital)H-Index: 86
2 CitationsSource
#1Myron Spector (Brigham and Women's Hospital)H-Index: 86
The number and percentage of people throughout the world who will be 60 years of age and older are steadily growing due to reduced fertility rate and longer life expectancy. We are facing the prospect that large numbers of individuals in countries throughout the world will be living longer with disability and pain resulting from age-related disorders. We have a wide array of biomedical materials that could serve as the basis for treatments to deal with these problems. It is important to begin no...
4 CitationsSource
#1Tomasz PiontekH-Index: 15
Last. Michał SłomczykowskiH-Index: 3
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ObjectiveTo collect and analyze the 2-year follow-up clinical and MRI results of patients treated with an arthroscopic technique of collagen membrane-based meniscus repair.Design53 consecutive patients with combined (horizontal and radial or longitudinal component) and complex meniscal tears (tear extended through avascular zones or/and composed with two or more morphological tear pattern) were treated with an “all-inside” arthroscopic suture of meniscus and wrapping with a collagen membrane (Ch...
27 CitationsSource
#1Henriette Jülke (University of Bern)H-Index: 1
#2Pierre Mainil-Varlet (University of Bern)H-Index: 34
Last. Dobrila Nesic (University of Bern)H-Index: 14
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Objective:Successful repair of defects in the avascular zone of meniscus remains a challenge in orthopedics. This proof of concept study aimed to investigate a guided tissue regeneration approach for treatment of tears in meniscus avascular zone in a goat model.Design:Full-depth longitudinal tear was created in the avascular zone of the meniscus and sutured. In the two treatment groups, porcine collagen membrane was wrapped around the tear without (CM) or with injection of expanded autologous ch...
17 CitationsSource
#1Thomas G. Baboolal (University of Leeds)H-Index: 10
#2Sally A. Boxall (University of Leeds)H-Index: 15
Last. Elena Jones (University of Leeds)H-Index: 42
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Aim: To enumerate and characterize multipotential stromal cells (MSCs) in a cellular bone allograft and compare with fresh age-matched iliac crest bone and bone marrow (BM) aspirate. Materials & methods: MSC characterization used functional assays, confocal/scanning electron microscopy and whole-genome microarrays. Resident MSCs were enumerated by flow cytometry following enzymatic extraction. Results: Allograft material contained live osteocytes and proliferative bone-lining cells defined as MS...
25 CitationsSource
Purpose The purpose of this study is to evaluate clinical and radiological outcomes of patients treated with autologous matrix-induced chondrogenesis (AMIC) for fullthickness chondral and osteochondral defects of the femoral condyles and patella. Method A retrospective evaluation of clinical and radiographic outcomes of patients treated with AMIC for chondral and osteochondral full-thickness cartilage defects of the knee was performed with a mean follow-up of 28.8 ± 1.5 months (range, 13–51 mont...
114 CitationsSource
#1W Brehm (University of Bern)H-Index: 6
#2B. Aklin (University of Bern)H-Index: 1
Last. Pierre Mainil-Varlet (University of Bern)H-Index: 34
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Summary Objective To compare four different implantation modalities for the repair of superficial osteochondral defects in a caprine model using autologous, scaffold-free, engineered cartilage constructs, and to describe the short-term outcome of successfully implanted constructs. Methods Scaffold-free, autologous cartilage constructs were implanted within superficial osteochondral defects created in the stifle joints of nine adult goats. The implants were distributed between four 6-mm-diameter ...
159 CitationsSource
#1Marc BohnerH-Index: 60
#1M. BohnerH-Index: 1
Last. Gamal BaroudH-Index: 28
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Recent studies have revealed that the ability of a calcium phosphate cement paste to harden in a physiological environment without desintegrating into small particles might be a key property to ensure a safe and reliable clinical use of calcium phosphate cements. However, this property called cohesion is not well understood and has not been studied extensively. The goal of the present study was to better understand which factors affect the cohesion of a calcium phosphate paste using the combinat...
96 CitationsSource
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