Sirt1 Suppresses Burn Injury-Induced Inflammatory Response through Activating Autophagy in Raw264.7 Macrophages
Abstract
The present study sought to investigate the association between silent information regulator 1 (SIRT1) and autophagy during systemic inflammatory response syndrome following burn injury. The experimental burn model in mice and macrophages were established. SIRT1 mRNA expression was quantified by quantitative real-time PCR. The protein levels of SIRT1 and the conversion of light chain 3 (LC3)-I to LC3-II were determined by western blot analysis....
Paper Details
Title
Sirt1 Suppresses Burn Injury-Induced Inflammatory Response through Activating Autophagy in Raw264.7 Macrophages
Published Date
Mar 1, 2021
Volume
69
Issue
3
Pages
761 - 767
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