Joint epitope selection and spacer design for string-of-beads vaccines
Abstract
Motivation Conceptually, epitope-based vaccine design poses two distinct problems: (i) selecting the best epitopes to elicit the strongest possible immune response and (ii) arranging and linking them through short spacer sequences to string-of-beads vaccines, so that their recovery likelihood during antigen processing is maximized. Current state-of-the-art approaches solve this design problem sequentially. Consequently, such approaches are...
Paper Details
Title
Joint epitope selection and spacer design for string-of-beads vaccines
Published Date
Dec 1, 2020
Journal
Volume
36
Issue
Supplement_2
Pages
i643 - i650
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Notes
History