Parathyroid hormone (1–34) can reverse the negative effect of valproic acid on the osseointegration of titanium rods in ovariectomized rats
Abstract
The present work was aimed to evaluate the effect of valproic acid (VPA),Parathyroid hormone (1-34) (PTH)+VPA on Ti rods osseointegration in ovariectomized rats and further investigation of the possible mechanism.The MC3T3-E1 cells were co-cultured with VPA,PTH + VPA and induced to osteogenesis, and the cell viability,mineralization ability were observed by MTT and ALP staining,Alizarin Red staining and Western blotting. Twelve weeks after...
Paper Details
Title
Parathyroid hormone (1–34) can reverse the negative effect of valproic acid on the osseointegration of titanium rods in ovariectomized rats
Published Date
Mar 1, 2021
Volume
27
Pages
67 - 76
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