AAV-CRB2 protects against vision loss in an inducible CRB1 retinitis pigmentosa mouse model

Volume: 20, Pages: 423 - 441
Published: Mar 1, 2021
Abstract
Loss of Crumbs homolog 1 (CRB1) or CRB2 proteins in Müller cells or photoreceptors in the mouse retina results in a CRB dose-dependent retinal phenotype. In this study, we present a novel Müller cell-specific Crb1KOCrb2LowMGC retinitis pigmentosa mouse model (complete loss of CRB1 and reduced levels of CRB2 specifically in Müller cells). The Crb double mutant mice showed deficits in electroretinography, optokinetic head tracking, and retinal...
Paper Details
Title
AAV-CRB2 protects against vision loss in an inducible CRB1 retinitis pigmentosa mouse model
Published Date
Mar 1, 2021
Volume
20
Pages
423 - 441
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