Original paper

Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site

Volume: 39, Issue: 2, Pages: 225 - 239.e8
Published: Feb 1, 2021
Abstract
TP53 is the most frequently mutated gene in cancer, yet these mutations remain therapeutically non-actionable. Major challenges in drugging p53 mutations include heterogeneous mechanisms of inactivation and the absence of broadly applicable allosteric sites. Here we report the identification of small molecules, including arsenic trioxide (ATO), an established agent in treating acute promyelocytic leukemia, as cysteine-reactive compounds that...
Paper Details
Title
Arsenic Trioxide Rescues Structural p53 Mutations through a Cryptic Allosteric Site
Published Date
Feb 1, 2021
Volume
39
Issue
2
Pages
225 - 239.e8
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