Interactions between insulin, the blood‐brain barrier, and beta‐amyloid in Alzheimer's disease

Background Defects in central response to insulin is suspected to play a role in AD. However, to act on the brain, pancreas‐secreted insulin must interact first with the blood‐brain barrier (BBB). The aim of the present study was to better understand mechanisms underlying transport and cell‐signaling of insulin at the BBB, and how they are altered in AD. Method We used microvessel‐enriched brain samples from individual classified as Controls,...