Polydopamine-based nanomaterials and their potentials in advanced drug delivery and therapy.

Published on Mar 1, 2021in Colloids and Surfaces B: Biointerfaces4.389
· DOI :10.1016/J.COLSURFB.2020.111502
Hanmei Li2
Estimated H-index: 2
Dan Yin2
Estimated H-index: 2
+ 3 AuthorsQiang Peng25
Estimated H-index: 25
(Sichuan University)
Abstract Polydopamine (PDA) has shown great potentials in biomedical fields due largely to its unique physicochemical properties, including high photothermal transfer efficiency, excellent drug binding capacity, versatile adhesion ability, sensitive pH responsibility and great biocompatibility and biodegradability. These properties confer PDA-based nanoparticles the potentials either as the drug carriers for advanced drug delivery or as the bioactive agents for photothermal therapy, imaging and biosensing. This review aims to provide a comprehensive understanding of PDA, its polymerization mechanisms and the potentials of PDA-based nano-systems in treating various diseases, including cancer, diabetes, inflammation, bacterial infection and Parkinson’s disease. In addition, the concerns of PDA in biomedical use are also discussed.
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