Co-expression of cancer driver genes: IDH-wildtype glioblastoma-derived tumorspheres

Background Driver genes of GBM may be crucial for the onset of isocitrate dehydrogenase ( IDH )-wildtype (WT) glioblastoma (GBM). However, it is still unknown whether the genes are expressed in the identical cluster of cells. Here, we have examined the gene expression patterns of GBM tissues and patient-derived tumorspheres (TSs) and aimed to find a progression-related gene. Methods We retrospectively collected primary IDH -WT GBM tissue samples...