Loss of IL-33 enhances elastase-induced and cigarette smoke extract-induced emphysema in mice

Volume: 22, Issue: 1
Published: May 15, 2021
Abstract
IL-33, which is known to induce type 2 immune responses via group 2 innate lymphoid cells, has been reported to contribute to neutrophilic airway inflammation in chronic obstructive pulmonary disease. However, its role in the pathogenesis of emphysema remains unclear.We determined the role of interleukin (IL)-33 in the development of emphysema using porcine pancreas elastase (PPE) and cigarette smoke extract (CSE) in mice. First, IL-33-/- mice...
Paper Details
Title
Loss of IL-33 enhances elastase-induced and cigarette smoke extract-induced emphysema in mice
Published Date
May 15, 2021
Volume
22
Issue
1
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