Glycyrrhizic acid-based self-assembled micelles for improving oral bioavailability of paeoniflorin

Paeoniflorin (Pae), a water-soluble monoterpene glucoside, has high potential clinical value in autoimmune and inflammatory diseases. However, the extremely low oral bioavailability of Pae (approximately 3%-4%) limits its formulation development and clinical application. This study aimed to develop micelles using the glycyrrhizic acid (GL) as the carrier to improve the oral absorption of Pae.Pae-loaded GL micelles were prepared by the ultrasonic...