Metformin protects chondrocytes against IL-1β induced injury by regulation of the AMPK/NF-κ B signaling pathway.

Osteoarthritis (OA) is a common joint disorder characterized by degeneration and inflammation of the articular cartilage. The etiology of OA is complex, and there is no effective drug for the treatment currently. Metformin, the first-line drug for type 2 diabetes mellitus, has been reported to play an essential role in a variety of diseases; however, whether it could be used in OA therapy remains unclear. In this study, we used interleukin-1β...