Network analysis to identify proteomic markers for brain aging and dementia in healthy older adults

Background Biological processes involved in preclinical stages of Alzheimer’s Disease and Related Dementias (ADRD) are not well understood. The plasma proteome is a promising tool to identify pathways involved in ADRD development, linking genetic and environmental risk factors with disease outcomes. The goal of this study is to leverage proteome data in a community‐based cohort to identify proteins and pathways involved in early stages of...