Long non-coding RNA NEAT1 promotes bone metastasis of prostate cancer through N6-methyladenosine
Abstract
Background N6-methyladenosine (m6A) is the most prevalent messenger RNA modification in mammalian cells. However, the disease relevant function of m6A on specific oncogenic long non-coding RNAs (ncRNAs) is not well understood. Methods We analyzed the m6A status using patients samples and bone metastatic PDXs. Through m6A high-throughput sequencing, we identified the m6A sites on NEAT1–1 in prostate bone metastatic PDXs. Mass spec assay showed...
Paper Details
Title
Long non-coding RNA NEAT1 promotes bone metastasis of prostate cancer through N6-methyladenosine
Published Date
Dec 1, 2020
Journal
Volume
19
Issue
1
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