<p>Experimental Carbonic Anhydrase Inhibitors for the Treatment of Hypoxic Tumors</p>
Volume: Volume 12, Pages: 603 - 617
Published: Dec 1, 2020
Abstract
: Carbonic anhydrase (CA, EC 4.2.1.1) isoforms IX and XII are overexpressed in many hypoxic tumors as a consequence of the hypoxia inducible factor (HIF) activation cascade, being present in limited amounts in normal tissues. These enzymes together with many others are involved in the pH regulation and metabolism of hypoxic cancer cells, and were validated as antitumor targets recently. A multitude of targeting strategies against these enzymes...
Paper Details
Title
<p>Experimental Carbonic Anhydrase Inhibitors for the Treatment of Hypoxic Tumors</p>
Published Date
Dec 1, 2020
Volume
Volume 12
Pages
603 - 617
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