MRI‐assessed locus coeruleus integrity is heritable and associated with cognition, Alzheimer’s risk, and sleep‐wake disturbance: Neuroimaging: Environmental and lifestyle factors

Published on Dec 7, 2020in Alzheimers & Dementia17.127
· DOI :10.1002/ALZ.044862
Jeremy A. Elman15
Estimated H-index: 15
(UCSD: University of California, San Diego),
Olivia K. Puckett1
Estimated H-index: 1
(UCSD: University of California, San Diego)
+ 6 AuthorsWilliam S. Kremen70
Estimated H-index: 70
Cited By2
#1Mara Mather (SC: University of Southern California)H-Index: 68
Many believe that engaging in novel and mentally challenging activities promotes brain health and prevents Alzheimer's disease in later life. However, mental stimulation may also have risks as well as benefits. As neurons release neurotransmitters, they often also release amyloid peptides and tau proteins into the extracellular space. These by-products of neural activity can aggregate into the tau tangle and amyloid plaque signatures of Alzheimer's disease. Over time, more active brain regions a...
1 CitationsSource
#1Martin J. Dahl (SC: University of Southern California)H-Index: 1
#2Mara Mather (SC: University of Southern California)H-Index: 68
Last. Helena C. Chui (SC: University of Southern California)H-Index: 91
view all 11 authors...
Abstract null Abnormally phosphorylated tau, an indicator of Alzheimer’s disease, accumulates in the first decades of life in the locus coeruleus (LC), the brain’s main norepinephrine supply. However, technical challenges in reliable in-vivo assessments have impeded research into the role of the LC in Alzheimer’s disease. null We studied participants with or known to be at-risk for mutations in genes causing autosomal-dominant Alzheimer’s disease (ADAD) of early onset, providing a unique window ...
5 CitationsSource