Two-year outcomes of the treat-and-extend regimen using aflibercept for treating diabetic macular oedema.

Published on Dec 16, 2020in Scientific Reports3.998
· DOI :10.1038/S41598-020-78954-3
Yu Cheol Kim2
Estimated H-index: 2
(KMU: Keimyung University),
Yu Cheol Kim7
Estimated H-index: 7
(KMU: Keimyung University)
+ 6 AuthorsJi Eun Lee19
Estimated H-index: 19
(PNU: Pusan National University)
This study was performed to investigate the efficacy of the treat-and-extend regimen using aflibercept for treating diabetic macular oedema (DME). This prospective, multicentre, interventional, single-arm, 104-week clinical trial included 48 patients with DME visual impairment. The patients' eyes received five consecutive intravitreal injections (2 mg aflibercept) every four weeks with two-week adjustments based on central subfield macular thickness (CSMT) changes. Injections were deferred when CSMT was stable. The number of injections, best-corrected visual acuity (BCVA), CSMT, and diabetic retinopathy severity scale scores were analysed. Compared to baseline, BCVA improved by + 9.1 letters at 52 weeks and was maintained with + 9.4-letter gain at 104 weeks (P < 0.001). Between baseline and 104 weeks, CSMT decreased from 489 to 298 μm (P < 0.001) and eyes with vision ≥ 20/40 increased from 17.4 to 43.5% (P = 0.007). The mean number of injections decreased from 8.5 in year one to 3.9 in year two. The injection interval was extended to ≥ 12 weeks in 56.5% of patients. The treat-and-extend regimen of aflibercept in DME showed 2-year efficacy comparable to that of fixed dosing regimens. The flexible dosing of this regimen reduced the number of injections in year two while maintaining efficacy.
#1Shinichiro Chujo (Mie University)H-Index: 1
#2Masahiko Sugimoto (Mie University)H-Index: 14
Last. Mineo Kondo (Mie University)H-Index: 53
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Background: To compare the effectiveness of intravitreal ranibizumab (IVR) and intravitreal aflibercept (IVA) performed with the treat-and-extend (TAE) regimen on eyes with diabetic macular edema (DME). Patients and methods: This is a retrospective study of 125 eyes of 125 treatment-naive DME patients who received anti-VEGF injections at three consecutive monthly intervals as the loading phase. The changes in the best-corrected visual acuity (BCVA), central retinal thickness (CRT), diabetic reti...
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#1Hiroki Mieno (Kyoto Prefectural University of Medicine)H-Index: 3
#2Kazuhito Yoneda (Kyoto Prefectural University of Medicine)H-Index: 9
Last. Chie Sotozono (Kyoto Prefectural University of Medicine)H-Index: 64
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PURPOSE To investigate the efficacy of aflibercept for the treatment of diabetic macular edema via a treat-and-extend regimen. METHODS This prospective, single-center, open-label, interventional study involved 30 patients with a best-corrected visual acuity (BCVA) ≤0.6 and a central retinal thickness (CRT) ≥300 μm. The enrolled eyes each received a monthly intravitreal aflibercept injection until the CRT decreased below 300 μm, upon which the administration interval was extended for 1 month unti...
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#1Beverley Curry (Hobart Corporation)H-Index: 2
#2Paul G. Sanfilippo (University of Melbourne)H-Index: 15
Last. Nitin VermaH-Index: 7
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Introduction Treat-and-extend (TE ‘as needed’) regimens of intravitreal anti-vascular endothelial growth factor (VEGF) treatment have been found to reduce the injection burden on patients and improve the cost effectiveness of the treatment of macular edema. The aim of this study was to assess the effectiveness of a T&E regimen of aflibercept, in a clinical setting, in patients with diabetic macular edema (DME) who were either intravitreal anti-VEGF therapy naive or with minimal exposure to anti-...
8 CitationsSource
#1Kang Yeun Pak (Inje University)H-Index: 3
#1Kang Yeun Pak (Inje University)H-Index: 7
Last. Ji Eun Lee (PNU: Pusan National University)H-Index: 19
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INTRODUCTION: The purpose of this study was to report the one-year results of treatment of diabetic macular edema (DME) with aflibercept using a treat-and-extend regimen (TER). METHODS: This was a prospective, multicenter, single-arm study planned for 2 years. The eyes received 5 consecutive intravitreal injections of 2 mg of aflibercept every 4 weeks, and the interval between injections was then adjusted by 2 weeks based on changes in the central subfield macular thickness (CSMT). If the CSMT w...
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#1John F. PayneH-Index: 18
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109 CitationsSource
#1Teresio Avitabile (University of Catania)H-Index: 24
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Purpose To compare monthly dosing with a treat and extend algorithm using ranibizumab 0.3 mg with and without angiography-guided macular laser photocoagulation for center-involving diabetic macular edema (DME). Design Multicenter, prospective, randomized clinical trial. Participants A total of 150 eyes from 116 subjects were randomized into 3 cohorts: Monthly (n = 30), TReat and EXtend without macular laser photocoagulation (TREX; n = 60), and treat and extend with angiography-GuIded macular LAs...
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Purpose To compare efficacy and safety of intravitreal aflibercept injection (IAI) with macular laser photocoagulation for diabetic macular edema (DME) over 3 years. Design Two similarly designed phase 3 trials: VISTA DME and VIVID DME . Participants Patients (eyes; n = 872) with central-involved DME. Methods Eyes received IAI 2 mg every 4 weeks (2q4), IAI 2 mg every 8 weeks after 5 monthly doses (2q8), or laser control. From week 24, if rescue treatment criteria were met, IAI patients received ...
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Cited By2
#1Wei-Hsuan Huang (Memorial Hospital of South Bend)
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#1Mathias Gallardo (University of Bern)H-Index: 2
#1Mathias Gallardo (University of Bern)H-Index: 1
Last. Raphael Sznitman (University of Bern)H-Index: 20
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