Engineering Metabolism in Nicotiana Species: A Promising Future

Published on Sep 1, 2021in Trends in Biotechnology14.343
· DOI :10.1016/J.TIBTECH.2020.11.012
Francisco Javier Molina-Hidalgo6
Estimated H-index: 6
(UGent: Ghent University),
Marta Vazquez-Vilar9
Estimated H-index: 9
(CSIC: Spanish National Research Council)
+ 6 AuthorsAlain Goossens63
Estimated H-index: 63
(UGent: Ghent University)
Sources
Abstract
Molecular farming intends to use crop plants as biofactories for high value-added compounds following application of a wide range of biotechnological tools. In particular, the conversion of nonfood crops into efficient biofactories is expected to be a strong asset in the development of a sustainable bioeconomy. The ‘nonfood’ status combined with the high metabolic versatility and the capacity of high-yield cultivation highlight the plant genus Nicotiana as one of the most appropriate ‘chassis’ for molecular farming. Nicotiana species are a rich source of valuable industrial, active pharmaceutical ingredients and nutritional compounds, synthesized from highly complex biosynthetic networks. Here, we review and discuss approaches currently used to design enriched Nicotiana species for molecular farming using new plant breeding techniques (NPBTs).
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