Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α

eLife7.70
Volume: 9
Published: Dec 8, 2020
Abstract
Metabolic dysfunction underlies several chronic diseases, many of which are exacerbated by obesity. Dietary interventions can reverse metabolic declines and slow aging, although compliance issues remain paramount. 17α-estradiol treatment improves metabolic parameters and slows aging in male mice. The mechanisms by which 17α-estradiol elicits these benefits remain unresolved. Herein, we show that 17α-estradiol elicits similar genomic binding and...
Paper Details
Title
Health benefits attributed to 17α-estradiol, a lifespan-extending compound, are mediated through estrogen receptor α
Published Date
Dec 8, 2020
Journal
Volume
9
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