Regulating surface roughness of electrospun poly(ε-caprolactone)/β-tricalcium phosphate fibers for enhancing bone tissue regeneration

Due to the natural microenvironment in the bone extracellular matrix, osteoblasts grow better on rougher and mechanically stronger substrates. Therefore, in this research, co-electrospinning poly(ε-caprolactone) (PCL) with β-tricalcium phosphate (β-TCP) was applied to simulate the organic/inorganic fibrous structure of the natural bone ECM, and the method of self-induced crystallization was implemented to generate two sizes of shish-kebab...