The crucial role of epigenetic regulation in breast cancer anti-estrogen resistance: Current findings and future perspectives
Abstract
Breast cancer (BC) cell de-sensitization to Tamoxifen (TAM) or other selective estrogen receptor (ER) modulators (SERM) is a complex process associated with BC heterogeneity and the transformation of ER signalling. The most influential resistance-related mechanisms include modifications in ER expression and gene regulation patterns. During TAM/SERM treatment, epigenetic mechanisms can effectively silence ER expression and facilitate the...
Paper Details
Title
The crucial role of epigenetic regulation in breast cancer anti-estrogen resistance: Current findings and future perspectives
Published Date
Jul 1, 2022
Journal
Volume
82
Pages
35 - 59
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