Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients

Science56.90
Volume: 371, Issue: 6529, Pages: 602 - 609
Published: Feb 5, 2021
Abstract
The gut microbiome has been shown to influence the response of tumors to anti-PD-1 (programmed cell death-1) immunotherapy in preclinical mouse models and observational patient cohorts. However, modulation of gut microbiota in cancer patients has not been investigated in clinical trials. In this study, we performed a phase 1 clinical trial to assess the safety and feasibility of fecal microbiota transplantation (FMT) and reinduction of anti-PD-1...
Paper Details
Title
Fecal microbiota transplant promotes response in immunotherapy-refractory melanoma patients
Published Date
Feb 5, 2021
Journal
Volume
371
Issue
6529
Pages
602 - 609
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