Deploying MMEJ using MENdel in precision gene editing applications for gene therapy and functional genomics

Volume: 49, Issue: 1, Pages: 67 - 78
Published: Dec 10, 2020
Abstract
Gene-editing experiments commonly elicit the error-prone non-homologous end joining for DNA double-strand break (DSB) repair. Microhomology-mediated end joining (MMEJ) can generate more predictable outcomes for functional genomic and somatic therapeutic applications. We compared three DSB repair prediction algorithms - MENTHU, inDelphi, and Lindel - in identifying MMEJ-repaired, homogeneous genotypes (PreMAs) in an independent dataset of 5,885...
Paper Details
Title
Deploying MMEJ using MENdel in precision gene editing applications for gene therapy and functional genomics
Published Date
Dec 10, 2020
Volume
49
Issue
1
Pages
67 - 78
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