Synthesis and cellular effects of a mitochondria-targeted inhibitor of the two-pore potassium channel TASK-3
Abstract
The two-pore potassium channel TASK-3 has been shown to localize to both the plasma membrane and the mitochondrial inner membrane. TASK-3 is highly expressed in melanoma and breast cancer cells and has been proposed to promote tumor formation. Here we investigated whether pharmacological modulation of TASK-3, and specifically of mitochondrial TASK-3 (mitoTASK-3), had any effect on cancer cell survival and mitochondrial physiology. A novel,...
Paper Details
Title
Synthesis and cellular effects of a mitochondria-targeted inhibitor of the two-pore potassium channel TASK-3
Published Date
Feb 1, 2021
Journal
Volume
164
Pages
105326 - 105326
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