Phosphorylation-dependent regulation of SPOP by LIMK2 promotes castration-resistant prostate cancer
Abstract
SPOP, an E3 ubiquitin ligase adaptor, can act either as a tumour suppressor or a tumour promoter. In prostate cancer (PCa), it inhibits tumorigenesis by degrading several oncogenic substrates. SPOP is the most altered gene in PCa (~15%), which renders it ineffective, promoting cancer. The remaining PCa tumours, which retain WT-SPOP, still progress to castration-resistant (CRPC) stage, indicating that other critical mechanisms exist for...
Paper Details
Title
Phosphorylation-dependent regulation of SPOP by LIMK2 promotes castration-resistant prostate cancer
Published Date
Dec 14, 2020
Journal
Volume
124
Issue
5
Pages
995 - 1008
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